Involvement of CETP (Cholesteryl Ester Transfer Protein) in the Shift of Sphingosine-1-Phosphate Among Lipoproteins and in the Modulation of its Functions.

Sphingosine-1-phosphate (S1P) is a vasoprotective lipid mediator. About two thirds of plasma S1P rides on high-density lipoprotein (HDL)， and several pleiotropic properties of HDL have been ascribed to S1P. In human subjects， CETP (cholesteryl ester transfer protein) greatly influences HDL quantities. In this study， we attempted to elucidate the roles of CETP in the metabolism of S1P.

apolipoproteins，hypercholesterolemia，mice，phosphorylation，sphingo